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Cardiovascular Disease and IPT

        One of the most important applications of IPT may turn out to be in cardiology.   The Drs. Perez Garcia and Dr. Paquette have apparently had some successes in this realm, although it has not been the major part of their practices.  There are many clues that further investigation of IPT for cardiology may be in order.

        Dr. Paquette, in his book Medicine of Hope, reports a case of a patient with myocardial infarction (heart attack), ischemic lesion of the heart muscle, and left cardiac insufficiency.   The patient was about to accept a coronary bypass operation.  After IPT treatment, in less than 10 days, all symptoms disappeared:  precordalgia, numbness, dizzy spells, edema, cyanosis, dyspnea with effort (difficulty breathing), and tension headaches.  Seven months later, he no longer needed surgery, and his cholesterol level was returned to normal.

Other clues:

1. The rapid and wonderful results of IPT for vascular disease in other parts of the body (see Vascular page).  The reported rapid disappearance with IPT of many vascular symptoms that cardiologists monitor:  high cholesterol, edema, unbalanced electrolytes.
   
   
2. The use of insulin in solutions to keep solitary organs (including hearts) alive for transplantation.  Apparently the insulin, by  increasing cell permeability, helps supply nutrients to cells and helps remove toxins from them without benefit of circulation.  Such cell permeability would no doubt be of great use in a heart, still in the body, which has impaired circulation.
   
   
3. The rapid healing of injured muscles, reduction of scars, and increased circulation with direct injection of small amounts of insulin, as reported by the US insulin study group of the 1930s, as reported in a 1977 article by Hal Huggins.
   
   
4. Insulin's known role as a cell growth factor and a stimulator of angiogenesis (growth of new blood vessels), both directly, and by cross-reaction with insulin-like growth factor 1 (IGF-1).
   
   
5. The apparent ability of IPT to stop inflammation and speed healing in cases of arthritis, and even necrotic bone (see Arthritis page).
   
   
6. The work by Demetrio Sodi Pallares MD in Mexico City on using GIK solution (glucose-insulin-potassium) for emergency cardiology treatment.  See articles.
   
   
7. Accumulating evidence that perhaps 80 percent of  atherosclerosis and heart disease may be caused by Chlamydia pneumoniae, a species of bacteria that may enter the bloodstream through the lungs, or even through gum infections.  IPT may be an ideal way of rapidly treating systemic infection with this bacterium, as both treatment and prevention for heart disease.
   
   
8. Rapid clearing of stroke-related paralysis (see Stroke/Paralysis page) with IPT may indicate multiple mechanisms at work, including nerve cell regeneration, and improved circulation.  Perhaps IPT can help reduce arrhythmias.  
   
   
9. A recent paper (Matthews KG, et al, J Endocrinol 1999 Dec; 163(3):433-445) shows that IGF-I and IGF-II are apparently closely involved in heart muscle events after infarcts (circulation blockages) in many roles, not only in the heart muscle cells, but also in macrophages (immune cells).  The authors hypothesize that these growth factors help maintain heart function by inducing swelling (hypertrophy) and increasing cell survival by decreasing  programmed cell death (apoptosis).  It is known that insulin can cross-react with IGF-I and IGF-II receptors, so externally applied (exogenous) insulin may help stimulate these same healing processes. 
   
   

Possibilities:

Here are my brainstorms about how IPT could be applied in the cardiology of the future.  I welcome dialogue, and hope that this may stimulate some further research.

1. Prevention.  Where there is indication of Chlamydia pneumoniae infection in the circulatory system, perhaps indicated by antibody tests, a prophylactic course of antibiotics (perhaps azithromycin) potentiated by IPT could perhaps clear the system and prevent disease.  
   
   
2. Emergency treatment.  GIK may be an effective treatment to increase survival rates during and after heart attacks.  But IPT may actually turn out to be better,  resulting in more rapid balancing of blood chemistry, and deeper systemic penetration of insulin, glucose, electrolytes, anticoagulants, and other medications to improve circulation, reduce swelling and shock, reduce inflammation, and speed healing.  Perhaps IPT added to streptokinase treatment would help obtain better results with less toxicity.  Magnesium is apparently helpful for keeping heart cells alive, so this could be added to the IPT protocol.
   
   
3. Chronic treatment.  Standard IPT treatment, perhaps with antibiotics to clear Chlamydia pneumoniae infection.  If results like those reported by Dr. Paquette are obtained, both patients and doctors will be very happy.
   
   
4. Pre-surgery preparation.  Perhaps IPT immediately before surgery (if it cannot be avoided) will reduce the doses and side effects of anesthesia, and will prepare the entire body for a longer period of reduced circulation and reduced oxygen.  It may also reduce reperfusion injury.