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This level:  
Syphilis 1938
Pyloric Stenosis
Donatian Therapy 1976
Uruguay 2003





This is the very first clinical trial of IPT , and the first with published data.  The technique used was based on IPT as practiced by Donato Perez Garcia and other IPT doctors, but with some modifications.  Nevertheless, the significantly better response of patients who received low dose chemotherapy with insulin potentiation certainly adds support to the decades of empirical observation by IPT doctors.  As the authors say, the results of this study suggest that it would be worthwhile to undertake further studies of insulin potentiation with other chemotherapy drug combinations and other tumor types.
--Chris Duffield 1/11/2004.

Cancer Chemother Pharmacol (2004) 53: 220–224  (2003 Dec 4 Epub ahead of print)
           Full Text   (PDF)              Archived full text
Insulin-induced enhancement of antitumoral response to methotrexate in breast cancer patients.

Lasalvia-Prisco E, Cucchi S, Vazquez J, Lasalvia-Galante E, Golomar W, Gordon W.

Department of Medicine, School of Medicine, University of Uruguay, Montevideo, Uruguay.

PURPOSE. It has been reported that insulin increases the cytotoxic effect in vitro of methotrexate by as much as 10,000-fold. The purpose of this study was to explore the clinical value of insulin as a potentiator of methotrexate. PATIENTS AND METHODS. Included in this prospective, randomized clinical trial were 30 women with metastatic breast cancer resistant to fluorouracil + Adriamycin + cyclophosphamide and also resistant to hormone therapy with measurable lesions. Three groups each of ten patients received two 21-day courses of the following treatments: insulin + methotrexate, methotrexate, and insulin, respectively. In each patient, the size of the target tumor was measured before and after treatment according to the Response Evaluation Criteria In Solid Tumors. The changes in the size of the target tumor in the three groups were compared statistically. RESULTS. Under the trial conditions, the methotrexate-treated group and the insulin-treated group responded most frequently with progressive disease. The group treated with insulin + methotrexate responded most frequently with stable disease. The median increase in tumor size was significantly lower with insulin + methotrexate than with each drug used separately. DISCUSSION. Our results confirmed in vivo the results of previous in vitro studies showing clinical evidence that insulin potentiates methotrexate under conditions where insulin alone does not promote an increase in tumor growth. Therefore, the chemotherapy antitumoral activity must have been enhanced by the biochemical events elicited in tumor cells by insulin. CONCLUSIONS. In multidrug-resistant metastatic breast cancer, methotrexate + insulin produced a significant antitumoral response that was not seen with either methotrexate or insulin used separately.

PMID: 14655024 [PubMed - as supplied by publisher]

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