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CURRICULUM VITAE
JACQUES BENVENISTE, MD Date and place of birth: 12 March 1935, 75009 Paris, France Married, 5 children -Baccalauréat, 1951 -Medical study at Faculté de Médecine de Paris, 1953-1960 University degrees: -Medical doctor, Faculté de Médecine de Paris, Thesis silver medal, 1967 -Chef de Clinique, Faculté de Médecine de Paris, 1967-1969 Hospital titles: -Externe des Hôpitaux de Paris, 1956 -Interne des Hôpitaux de la Région de Paris, 1959 -Interne des Hôpitaux de Paris, 1961 -Assistant des Hôpitaux de Paris, 1967 -Part-time researcher at Institut de Recherche sur le Cancer, CNRS, Villejuif (Dr. J.C. Salomon and Prof. W. Bernhardt), 1965-1969 -Research Associate, Department of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California (Drs C.G. Cochrane and F.J. Dixon), 1969-1972 (Fellowship from International Center for Research on Cancer) -Chargé de Recherches, INSERM Unit 25, Hôpital Necker, Paris, 1973 -Head of the Research Laboratory on Immediate Hypersensitivity and Immunopathology, INSERM Unit 25, 1977 -Directeur de Recherche 2ème Classe INSERM, INSERM Unit 131, Clamart, 1978 -Head of INSERM Unit 200: Immunology of Allergy and Inflammation, Clamart, 1980 -Directeur de Recherche 1ère Classe INSERM, 1984 -Head of Digital Biology Laboratory, Clamart, 1995
-Discovery of "Platelet-Activating Factor", 1970 -Author of the controversial article on the "memory of water", Nature, 1988, which lead to the recent development of Digital Biology.
- BENVENISTE J, HENSON PM, COCHRANE CG: Leukocyte-dependent histamine release from rabbit platelets: the role of IgE, basophils and a platelet-activating factor. J EXP MED, 1972, 13:1356-1377.** - BENVENISTE J: Platelet-activating factor, a new mediator of anaphylaxis and immune complex deposition from rabbit and human basophils. NATURE, 1974, 249:581-582. - BENVENISTE J, LE COUEDIC JP, POLONSKY J, TENCE M: Structural analysis of purified platelet-activating factor by lipases. NATURE, 1977, 269:170-171. - CHIGNARD M, LE COUEDIC JP, TENCE M, VARGAFTIG BB, BENVENISTE J: The role of platelet-activating factor in platelet aggregation. NATURE ,1979, 279:799-800. - BENVENISTE J, TENCE M, VARENNE P, BIDAULT J, BOULLET C, POLONSKY J: Semi-synthèse et structure proposée du facteur activant les plaquettes (PAF) : PAF-acéther, un alkyl éther analogue de la lysophosphatidylcholine. C R ACAD SCI PARIS, 1979, 289, série D:1037-1040.** - CHAP H, MAUCO G, SIMON MF, BENVENISTE J, DOUSTE-BLAZY L: Biosynthetic labelling of platelet-activating factor (paf-acether) from radioactive acetate by stimulated platelets. NATURE, 1981, 289:312-314. - DAVENAS E, BEAUVAIS F, AMARA J, OBERBAUM M, ROBINZON B, MIADONNA A, TEDESCHI A, POMERANZ B., FORTNER P, BELON P, SAINTE-LAUDY J, POITEVIN B, BENVENISTE J: Human basophil degranulation triggered by very dilute antiserum against IgE. NATURE, 1988, 333-816-818. - BENVENISTE J, DAVENAS E, DUCOT B., CORNILLET B., POITEVIN B, SPIRA A: L'agitation de solutions hautement diluées n'induit pas d'activité biologique spécifique. C R ACAD SCI PARIS,1991,312,série II:461-466. - BEAUVAIS F, SHIMAHARA T, INOUE I, BENVENISTE J: Anti-IgE induces the opening of non selective cation channels on human basophils. FUNDAM CLIN PHARMACOL, 1994, 8:246-250. - NGUER CM, PELLEGRINI O, GALANAUD P, BENVENISTE J, THOMAS Y, RICHARD Y: Regulation of paf-acether receptor expression in human B cells. J IMMUNOL, 1992, 149:2742-2748. - CALABRESSE C, NGUER CM, PELLEGRINI O, BENVENISTE J, RICHARD Y, THOMAS Y: Induction of high-affinity paf-acether receptor expression during T cell activation. EUR J IMMUNOL, 1992, 22:1349-1355. - BEAUVAIS F, HIEBLOT C, BURTIN C, BENVENISTE J: Regulation of human basophil activation. III. Impairment of the inhibitory effect of Na+ on IgE-mediated histamine release in patients with allergic rhinitis. J ALLERGY CLIN IMMUNOL, 1992, 90:52-58. - BEAUVAIS F, HIEBLOT C, BURTIN C, BENVENISTE J: Regulation of human basophil activation. IV. Dissociation between cationic dye binding and histamine release: role of Ca2+ ions. FUNDAM CLIN PHARMACOL, 1992, 6:153-158. - EL AZZOUZI B, JURGENS P, BENVENISTE J, THOMAS Y: Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature human T cell line. BIOCHEM BIOPH RES COMMUN, 1993, 190:320-324. - BIDET B, LEBOYER M, DESCOURS B, BOUVARD MP, BENVENISTE J: Allergic sensitization in infantile autism. J AUTISM DEVELOP DISORD, 1993, 23:419-420. - PELLEGRINI O, DAVENAS E, MORIN L, BENVENISTE J, MANUEL Y, THOMAS Y: Stress proteins in human lymphocytes. II. Modulation of stress proteins in a human T cell line. EUR J PHARMAC, 1994, 270:221-228. - EL AZZOUZI B, TSANGARIS G, PELLEGRINI O, BENVENISTE J, MANUEL Y, THOMAS Y: Cadmium induces apoptosis in a human T cell line. TOXICOLOGY, 1994, 88:127-139. - HILLIQUIN P, NATOUR J, AISSA J, GUINOT P, LAOUSSADI S, BENVENISTE J, MENKES CJ, ARNOUX B: Treatment of carrageenan-induced arthritis by platelet-activating factor (paf) antagonist BN 50730. ANN RHEUM DIS, 1995, 54:140-143. - HILLIQUIN P, HARRAN H, AISSA J, BENVENISTE J, MENKES CJ: Correlations between paf-acether and tumor necrosis factor in rheumatoid arthritis. SCAND J RHEUM, 1995, 24:169-173. - GUIMBAUD R, IZZO A, MARTINOLLE JP, VIDON N, COUTURIER D, BENVENISTE J, CHAUSSADE S: Intraluminal excretion of paf, lysopaf, and acetylhydrolase in patients with ulcerative colitis. DIGEST DIS SCI, 1995, 40:2635-2640. - KORTH RM, HIRAFUJI M, BENVENISTE J, RUSSO-MARIE F: Human umbilical vein endothelial cells: specific binding of platelet-activating factor and cytosolic calcium flux. BIOCHEM PHARMAC, 1995, 49:1793-1799. -- AÏSSA J, HARRAN H, RABEAU M, BOUCHERIE S, BROUILHET H, BENVENISTE J: Tissue levels of histamine, paf-acether and lysopaf-acether in carrageenan-induced granuloma in rats. INT ARCH ALLERGY IMMUNOL, 1996, 110:182-186. * Selected from about 300, including 26 publications in J IMMUNOL from 1971 to 1994 ** CURRENT CONTENTS "Citation Classic". |